IMUCLONE™ TAFI ELISA, 96 microwell plate

Measures TAFI antigen in human plasma.Thrombin Activatable Fibrinolytic Inhibitor (TAFI), also known as plasma procarboxypeptidase U and procarboxypeptidase B, is converted to its active form (TAFIa) by the thrombin/thrombomodulin complex. TAFIa possesses a preference for cleaving lysine and arginine residues from the C-terminus of proteins. Modulation of fibrinolysis occurs when TAFIa cleaves C-terminal arginine and lysine residues of partially degraded fibrin. The removal of the C-terminus arginine and lysine residues from fibrin inhibits the continued degradation of fibrin by tPA-activated plasmin. TAFI may play a central role in thrombosis and fibrinolysis due to its ability to retard fibrin clot lysis. For Research Use Only