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DVVtest® is a simplified single-vial dilute Russell's Viper Venom Time (dRVVT) test reagent for the determination of Lupus Anticoagulant (LA) in plasma.
The reagent contains Russell's Viper Venom that directly activates Factor X to Factor Xa in the presence of phospholipids and calcium. Factor Xa c..
Measures ADAMTS13 IgG autoantibodies in human plasma.Studies have shown that low levels of ADAMTS13 activity are associated with Thrombotic Thrombocytopenia Purpura (TTP), a life-threatening hematological condition characterized by low platelet count, microvascular thrombi, red cell fragmentation, C..
Measures ADAMTS13 protein in human plasma.ADAMTS13 is a metalloproteinase that cleaves ultra large (UL) vWF multimers within the A2 region of vWF. Studies have shown that low levels of ADAMTS13 activity are associated with Thrombotic Thrombocytopenia Purpura (TTP), a life-threatening hematological c..
Measures human Plasminogen Activator Inhibitor Type-1 (PAI-1) antigen in plasma.As a primary regulator of fibrinolysis, PAI-1 is found in a number of tissues and cell types, including macrophages/monocytes, hepatocytes, vascular endothelia, adipose tissue of the heart and lungs and in platelets. Lev..
Measures thrombomodulin in human plasma, serum and cell culture supernatants.Thrombomodulin (TM) is the endothelial cell surface receptor for thrombin. When occupied, the thrombomodulin/thrombin complex activates Protein C. Following Protein C activation, thrombomodulin acts as a major anticoagulant..
Measures human tissue factor (TF, Thromboplastin, Factor III) in plasma, tissue extracts and cell culture supernatants.Tissue factor (TF) is membrane-bound glycoprotein that serves as both the receptor and cofactor for Factor VII (fVII) and Factor VIIa (fVIIa) in initiating cell surface procoagulant..
Measures human PAI-1 in tissue extracts and cell culture supernatant.As a primary regulator of fibrinolysis, PAI-1 is found in a number of tissues and cell types, including macrophages/monocytes, hepatocytes, vascular endothelia, adipose tissue of the heart and lungs and in platelets. The assay meas..
Measures vWF antigen in human plasma.vWF functions as a carrier protein for Factor VIII, the coagulation protein absent in Hemophilia A. It promotes platelet adhesion to damaged endothelium and participates in the platelet-to-platelet cohesion necessary for thrombus formation. Together with fibronec..
Measures D-dimer, cross linked fibrin degradation product (XL-FDP), in human plasma.Elevated XL-FDP levels indicate reactive fibrinolysis and are found in a number of arterial and venous occlusive disease states, including acute Myocardial Infarction (MI), Deep Vein Thrombosis (DVT), Pulmonary Embol..
Measures human plasma fibronectin levels, particularly in patients with severe trauma, shock, sepsis, hepatic disease or clotting disorders. For research use only.
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Measures Free Protein S in human plasma.Protein S is a Vitamin K dependent glycoprotein synthesized in the liver. In normal human plasma, Protein S is present in two forms: Free Protein S (40% of total Protein S concentration) and Protein S complexed with C4b binding protein (C4b-BP). Only Free Prot..
Measures TAFI antigen in human plasma.Thrombin Activatable Fibrinolytic Inhibitor (TAFI), also known as plasma procarboxypeptidase U and procarboxypeptidase B, is converted to its active form (TAFIa) by the thrombin/thrombomodulin complex. TAFIa possesses a preference for cleaving lysine and arginin..