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ACE Liquid

ACE Liquid

Brand:SENTINEL
Product Code:1767001
Price: £POA

Features and Advantages

  • Mono Reagent liquid and ready to use
  • 18 months stability from date of manufacture
  • Linearity up to 120 U/L
  • Sensitivity: 5.8 U/L
  • 30 days on-board reagent stability
  • 30 days on-board calibration stability
  • Excellent correlation with other similar methods available on the market
  • High lot-to-lot consistency
  • Reagents filled in Universal Vials* suitable for AU series, ADVIA series, Roche Modular, Hitachi 917, DIRUI series, Mindray BS-800
  • Available for the US market
  • Registered under FDA 510 (k) approval number K141728**


Summary
ACE is a zinc dependent peptidase which has a major role in the metabolism of vasoactive peptides and hence in the regulation of blood pressure, converting the relatively inactive decapeptide Angiotensin I to the potent vasoconstrictor Angiotensin II.
Serum ACE is often elevated in patients with untreated active sarcoidosis, an inflammatory disease of unknown origin characterized by the formation of small clumps affecting eyes, lungs, lymph nodes and skin. The measurement of ACE levels can assist in diagnosing Sarcoidosis, and in monitoring the effectiveness of steroid therapy.
Other diseases in which ACE may be elevated include Gaucher’s disease, leprosy, tuberculosis and pathologic conditions involving lung and liver diseases.

Principle
The hydrolysis of FAPGG (furylacryloylphenylalanine-glycylglycine) to FAP (furylacryloylphenylalanine) is catalyzed by ACE enzyme. Hydrolysis of FAPGG results in a decrease in absorbance at 340 nm. The ACE activity in the sample is determined by comparing the sample reaction rate to that obtained with the Sentinel ACE calibrator.

 

Method comparison


 
Precision (1)
Mean (U/L) Total (CV %) Repeatibility (CV %)
40.4 2.9 2.6
64.6 2.7 1.0
112.1 1.7 0.6
(1) Precision studies conducted on an automated analyzer
according to NCCLS EP-7 protocol.

 
Ref. Description Kit Size
1767001* ACE Liquid 2x20 mL
1665001** ACE Calibrator 3x1 mL
1667001 ACE Control Set 2x(3x1 mL)