ED-FMPO200

The DIASTAT™ anti-myeloperoxidase (anti-MPO) test is a quantitative/qualitative enzyme-linked immunosorbent assay (ELISA) for the detection of autoantibodies specific for myeloperoxidase antigen in human serum or plasma. It is intended to aid in the diagnosis of conditions associated with raised levels of anti-neutrophil cytoplasmic antibodies (ANCA) and is not definitive in isolation. MPO-ANCA is associated with Churg-Strauss syndrome, microscopic polyarteritis and necrotising glomerulonephritis. Autoantibody levels represent one parameter in a multicriterion diagnostic process.

References

Davies D.J., et al. 1982. Segmental necrotizing glomerulonephritis with antineutrophil antibody; Possible abovirus aetiology. Br Med J 285: 606.

Hagen E., et al. 1993. Antineutrophil cytoplasmic autoantibodies; A review of the antigens involved, the assays and the clinincal and possible pathogenetic consequences. Blood 81 (April 15): 19662002.

Gross W.L., et al. 1993. ANCA and associated diseases; Immunodiagnostics and pathogenic aspects. Clin Exp Immunol. 91: 1-12.

Roberts D.E.R., 1992. Antineutrophil cytoplasmic antibodies. Laboratory Immunology 12, No. 1, March.

Lesavre P., et al. 1991. Antineutrophil cytoplasmic autoantibodies antigen specificity. Am J Kidney Dis 18: 159.

Hauschild S., et al. Antineutrophil cytoplasmic antibodies in systemic vasculitides, collagen vascular diseases, rheumatic disorders and inflammatory bowel diseases. In: Gross W.L. Ed. ANCA associated vasculitides: London: Plenum Press, in press.

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