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Measures human PAI-1 in tissue extracts and cell culture supernatant.As a primary regulator of fibrinolysis, PAI-1 is found in a number of tissues and cell types, including macrophages/monocytes, hepatocytes, vascular endothelia, adipose tissue of the heart and lungs and in platelets. The assay meas..
Measures human urokinase-type plasminogen activator (uPA) in tissue extracts, plasma and cell culture supernatant.Single chain uPA (sc-uPA, pro-uPA) and HMW-uPA forms of urokinase-type plasminogen activator are recognized by the assay, as are receptor-bound uPA and uPA complexed with PAI-1 and PAI-2..
Measures vWF activity in human plasma by making use of a monoclonal antibody that recognizes a functional epitope of the vWF molecule.vWF functions as a carrier protein for Factor VIII, the coagulation protein absent in Hemophilia A. It promotes platelet adhesion to damaged endothelium and participa..
Measures vWF antigen in human plasma.vWF functions as a carrier protein for Factor VIII, the coagulation protein absent in Hemophilia A. It promotes platelet adhesion to damaged endothelium and participates in the platelet-to-platelet cohesion necessary for thrombus formation. Together with fibronec..
Measures human Annexin V in plasma, platelet and blood cell concentrates and other biological fluid or cell culture supernatant in which Annexin V may be present. This assay recognizes both native and recombinant Annexin. For research use only.
Measures D-dimer, cross linked fibrin degradation product (XL-FDP), in human plasma.Elevated XL-FDP levels indicate reactive fibrinolysis and are found in a number of arterial and venous occlusive disease states, including acute Myocardial Infarction (MI), Deep Vein Thrombosis (DVT), Pulmonary Embol..
A competitive assay which measures human Fibrinopeptide A (FPA) on bentonite absorbed human plasma.FPA is cleaved from the amino terminus of fibrinogen A-alpha chains by thrombin. Elevated blood levels of FPA are indicative of excess thrombin activity and are found in various clinical states such as..
Measures Free Protein S in human plasma.Protein S is a Vitamin K dependent glycoprotein synthesized in the liver. In normal human plasma, Protein S is present in two forms: Free Protein S (40% of total Protein S concentration) and Protein S complexed with C4b binding protein (C4b-BP). Only Free Prot..
Measures plasmin/alpha-2-antiplasmin (PAP) complexes in human plasma.Alpha-2-antiplasmin is consumed during thrombolytic therapy. Measurement of PAP complexes may provide information on the extent of plasminemia and therefore the possibility of hemorrhagic events. Increased PAP complex formation is ..
Measures Platelet Factor 4 (PF4) in platelet depleted human plasma.PF4 is released from activated platelet alpha granules upon platelet activation. PF4 possesses a powerful anti-heparin activity as it binds to heparin, forming a stochiometric complex. Elevated levels of PF4 are observed in various s..
Measures TAFI antigen in human plasma.Thrombin Activatable Fibrinolytic Inhibitor (TAFI), also known as plasma procarboxypeptidase U and procarboxypeptidase B, is converted to its active form (TAFIa) by the thrombin/thrombomodulin complex. TAFIa possesses a preference for cleaving lysine and arginin..