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Ecarin is a metalloprotease isolated from the venom of the saw-scaled viper (Echis carinatus) that activates prothrombin. Ecarin does not affect other clotting factors. The action of ecarin on prothrombin is independent of calcium, phospholipids and factor V. Moreover, Ecarin, in contrast to factor ..
Prepared from factor IX isolated from pooled normal plasma. Proteolytic factor XIa activation and activator removal employing factor XIa immunoabsorbtion, to yield a heavy-chain containing the serine protease catalytic domain, the light-chain membrane binding domain and the activation glycopeptide.
Specific factor V activator from Russell’s viper venom (RVV-V). RVV-V is a serine proteinase, which converts the single-chain coagulation factor V into a light chain (80 kDa) and a heavy chain (230 kDa) with higher coagulant activity (factor Va). Apart from factor V, no other protein substrate for R..
Human glu-plasminogen (88 kDa) is prepared from fresh human citrated plasma by lysine-Sepharose affinity chromatography in the presence of aprotinin to minimize any plasmin contamination. This is followed by gel filtration with Sephacryl 200. Treatment with aprotinin-Sepharose is carried out prior t..